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NanoSphere Health Sciences and Vertical Companies™ Commence Production in California

Award-Winning Evolve Formulas Transdermal NanoSerum™ To Hit
Dispensary Shelves in the Golden State in Time for the Holidays

DENVER–(BUSINESS WIRE)–NanoSphere
Health Sciences, Inc.
(CSE:NSHS) (OTC:NSHSF), the biotechnology
leader behind the patented NanoSphere Delivery System™, in partnership
with Vertical™,
the largest fully integrated company in the legal medical cannabis
industry, has officially started production to bring its commercial
cannabis brand, Evolve Formulas, into the California market.


NanoSphere announced its licensing agreement with Vertical earlier this
year. Vertical will provide planning, permitting, development and
operation of cultivation, extraction, manufacturing, distribution and
retail facilities in California and other markets across the country in
the coming months. As the largest fully integrated company in the
medical cannabis industry, Vertical utilizes a 1.2 million square foot
grow facility to supply over 220 retail outlet stores including the
production of approximately 250,000 grams of oil per month.

“We’re thrilled to break ground and enter the next phase of our
partnership with industry leader Vertical by bringing our patented
technology to the world’s largest legal cannabis market,” said Robert
Sutton, Chairman and CEO of NanoSphere Health Sciences and Evolve
Formulas. “With California representing nearly a third of the North
American cannabis market, the commencement of production in this
powerhouse state marks an enormous step for the Evolve Formulas brand in
our national expansion strategy. We are eager to soon share our
cutting-edge solutions with a broad audience of consumers in California
and beyond.”

“Vertical was proud to present Evolve by NanoSphere at the recent Hall
of Flowers trade show for the California legal cannabis industry. As we
presented our 25 brands to hundreds of licensed cannabis retailers of
California, Evolve stood out for its unique value proposition to
patients everywhere,” said J. Smoke Wallin, President of Vertical. “This
has led to a backlog of preorders from accounts waiting for us to launch
with California compliant packaging in November. The market can’t wait!”

NanoSphere’s cannabis product line, Evolve Formulas, consists of two
variations of Transdermal NanoSerum™ applicators, one THC-dominant and
one CBD-dominant in formula. Both products leverage the breakthrough
NanoSphere Delivery System™, which nano-encapsulates cannabinoid
molecules in lipid membranes for transportation through the skin and
into the bloodstream within minutes. The result is high bioavailability,
minimal wait-time, precision-metered dosing and elimination of adverse
side effects. This patented technology is the first and only advanced
nanoparticle cannabinoid delivery system and can only be found in
NanoSphere Health products.

Evolve Formulas is currently available in over 200 dispensaries in
Colorado, with hemp-based products soon to launch in Indiana. California
is the first of numerous markets across the country to begin
manufacturing the Evolve Formulas products under NanoSphere Health
Sciences’ licensing partnership with Vertical.

For more information on NanoSphere Health Sciences, Inc. or to schedule
an interview, please contact Gabrielle Wesseldyk at media@nanospherehealth.com
or 212-255-0945.

NanoSphere’s Commitment to Licensing IP

NanoSphere launched its IP licensing program in 2015 and is entertaining
several licensing opportunities via a rigorous evaluation process. For
more information about NanoSphere’s licensing program, please visit: https://www.nanospherehealth.com/licensing/

About NanoSphere

NanoSphere Health Sciences, Inc. is a biotechnology firm specializing in
the creation of the patented NanoSphere Delivery System™, a
revolutionary platform using nanotechnology in the biodelivery of
supplements, nutraceuticals and over-the-counter medications for the
cannabis, pharmaceutical and animal health industries, and beyond.
Covered by U.S. Patent No. 10,028,919 and U.S. Patent No. 9,925,149,
NanoSphere Delivery System™ represents one of the most important
developments for advancing the non-invasive and user-friendly delivery
of biological agents in over 25 years. For more information on
NanoSphere, please visit http://www.nanospherehealth.com.

About Evolve Formulas

Evolve Formulas is the provider of the world’s first and only
scientifically proven nanoparticle delivery system in cannabis. Evolve’s
pioneering product, Transdermal NanoSerum™, is a fast-acting,
ultra-strength transdermal formula infused with nano-encapsulated
cannabis and cannabis extracts. NanoSerum™ immediately penetrates the
skin to deliver direct-focused results and intelligently carries a full
spectrum of cannabinoids and phytochemicals to receptors throughout the
body for systemic healing. Evolve Formula products leverage NanoSphere
Health Sciences™ patented NanoSphere Delivery System™. The NanoSphere
Delivery System™ is a revolutionary platform using nanotechnology in the
biodelivery of supplements, nutraceuticals and over-the-counter
medications for the cannabis, pharmaceutical and animal health
industries, and beyond. For more information on Evolve Formulas, visit https://www.evolveformulas.com/.
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About Vertical™

Vertical is one of the first and largest vertically integrated companies
in the legal medical cannabis industry. We have operations in CA and AZ,
combined with strategic partnerships in CO, MI, OR, and other markets
which position us well to take advantage of the legalization and
normalization of cannabis globally. Vertical is led by an executive team
of entrepreneurs and business leaders from the alcohol beverage,
agriculture, CPG, distribution, entertainment, food, healthcare and
medical industries. Vertical’s operations include planning, permitting,
development and operation of cultivation, extraction, manufacturing,
distribution and brands. We have world class capabilities in product
development, co-packing, branding, marketing, distribution, education,
and legal compliance. Vertical does Everything Pertaining to Green.

The Canadian Securities Exchange does not accept responsibility for
the adequacy or accuracy of this release.

Forward Looking Statement Caution

This news release includes forward looking statements that are
subject to assumptions, risks and uncertainties. Statements in this news
release which are not purely historical are forward looking statements,
including without limitation any statements concerning the Company’s
intentions, plans, estimates, expectations or beliefs regarding the
future. Although the Company believes that any forward looking
statements in this news release are reasonable, there can be no
assurance that any such forward looking statements will prove to be
accurate. The Company cautions readers that all forward looking
statements, including without limitation those relating to the Company’s
future operations and business prospects, are based on assumptions none
of which can be assured, and are subject to certain risks and
uncertainties that could cause actual events or results to differ
materially from those indicated in the forward looking statements.
Readers are advised to rely on their own evaluation of such risks and
uncertainties and should not place undue reliance on forward looking
statements. Any forward looking statements are made as of the date of
this news release, and the Company assumes no obligation to update the
forward looking statements, or to update the reasons why actual events
or results could or do differ from those projected in the forward
looking statements, whether as a result of new information, future
events or otherwise.

Contacts

On behalf of the Board
Robert Sutton, 720-520-4282
Chairman
and CEO
rsutton@nanospherehealth.com
or
NanoSphere
Health Sciences, LLC

Gabrielle Wesseldyk, 212-255-0945
gabrielle@rosengrouppr.com
or
Investor
Contact:

Victor Goncalves, 204-997-5517
Executive Vice
President
vgoncalves@nanospherehealth.com