Intermountain Healthcare and deCODE genetics Launch Groundbreaking DNA Study of 500,000 People to Find New Links Between Genetics and Disease

Study Represents Largest DNA Mapping Effort Undertaken in U.S.
From a Single Population

REYKJAVIK, Iceland & SALT LAKE CITY–(BUSINESS WIRE)–#Healthcare–Intermountain Healthcare and deCODE genetics have announced a major
global collaboration and study focused on discovering new connections
between genetics and human disease that will involve the collection of
half a million DNA samples.

The initiative, called the HerediGene: Population Study, represents the
largest and most comprehensive DNA mapping effort to date in the United
States from a single population. For the study, which is voluntary and
free to participants, Intermountain teams will work with deCODE to
analyze the genomes of 500,000 people from Intermountain’s patient
population, primarily in Utah and Idaho.

Intermountain Healthcare is a Utah-based not-for-profit integrated
healthcare delivery network, and deCODE genetics is a wholly owned
subsidiary of Amgen based in Reykjavik, Iceland. The collaborative
effort combines Intermountain’s internationally-recognized expertise in
precision medicine and clinical care with deCODE’s world-class expertise
in human population genetics.

“While the 500,000 samples will be collected primarily from patients in
Utah, the research is expected to have a global impact as medications,
treatments, and healthcare innovations that can benefit patients
universally are developed from the findings,” said Lincoln Nadauld, MD,
PhD, Intermountain’s chief of precision health. “The collaboration is
noteworthy and unique in its size, scope, and immediate application to
patient care.”

Participants in the study will consent to the testing and have the
option to receive their genetic results report, if a clinically
significant gene mutation is identified. The data will be de-identified
to ensure anonymity before it is utilized in research to help medical
professionals better understand the human genome, which will enhance
their ability to predict and prevent diseases such as breast cancer,
colon cancer, and heart disease.

“This unique collaboration is expected to uncover new insights into some
of society’s most debilitating diseases,” noted Kári Stefánsson, MD, Dr.
Med., founder and chief executive officer of deCODE genetics. “Our
partnership with Intermountain Healthcare is important as we continue to
identify and validate human disease targets. These potential discoveries
will allow deCODE and Amgen to rapidly develop new medicines that reach
the right disease targets.”

Intermountain will leverage its renowned precision genomics efforts to
improve patient outcomes and transform medicine. Intermountain’s
precision medicine team analyzes individual differences in genetics,
environments, and lifestyles and helps medical professionals
specifically target the illnesses of each patient and identify the
treatments that will best help them.

“Better health and being able to cure common diseases is the promise of
precision medicine, but it’s not happening fast enough,” said Marc
Harrison, MD, president and chief executive officer at Intermountain
Healthcare. “For too long, the genetic code to better health has been
locked. This collaboration with deCODE unlocks that insight so we can
rapidly advance well-being – not only for ourselves and our families,
but for generations to come.”

Insights from the collaboration may power fundamental changes to better
understand the human genome, improve health, and prevent common diseases.

For more information on the study, please go to
Intermountainhealthcare.org/heredigene.

About deCODE genetics

Based in Reykjavik, Iceland, deCODE is a global leader in analyzing and
understanding the human genome. Using its unique expertise and
population resources, deCODE has discovered genetic risk factors for
dozens of common diseases. Understanding the genetics of disease can
create new means of diagnosing, treating and preventing disease. deCODE
is a wholly-owned subsidiary of Amgen.

About Intermountain

Intermountain Healthcare is a Utah-based not-for-profit system of 24
hospitals, 160 clinics, a Medical Group with some 2,300 employed
physicians and advanced care practitioners, a health insurance company
called SelectHealth, and other health services. Intermountain is widely
recognized as a leader in transforming healthcare through evidence-based
best practices, high quality, and sustainable costs. For more
information about Intermountain, visit intermountainhealthcare.org.

Amgen Forward-Looking Statements

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Contacts

Media Contacts:
Intermountain Healthcare:
Brad Gillman: brad.gillman@imail.org
385-315-8949

deCODE genetics:
Jon Gustafsson: jon@decode.is
+354
664 1905

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